| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel combinational approach for the treatment of cancer comprising a nucleic acid based therapeutic delivered with a polymeric carrier and at least one chemotherapeutic agent, for the treatment of mammalian cancer or hyperproliferative disorders.SOLUTION: This invention relates to: pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug; and a method for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection, in which the gene delivery polymer is a lipopolymer comprising a polyethylenimine backbone covalently linked with a lipid and a polyethylene glycol, and at least one pharmaceutical agent for the treatment of cancer or hyperproliferative disorders. The pharmaceutical agent is selected from the group consisting of chemotherapeutic drugs, anti-angiogenic agents, anti-cancer peptides, monoclonal antibodies and mixtures thereof. |
