发明名称 |
3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH |
摘要 |
<p>The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.</p> |
申请公布号 |
CA2903979(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
CA20142903979 |
申请日期 |
2014.03.12 |
申请人 |
NOVARTIS AG |
发明人 |
CAFERRO, THOMAS RAYMOND;CHEN, ZHUOLIANG;CHO, YOUNG SHIN;COSTALES, ABRAN Q.;LEVELL, JULIAN ROY;LIU, GANG;MANNING, JAMES R.;SENDZIK, MARTIN;SHAFER, CYNTHIA;SHULTZ, MICHAEL DAVID;SUTTON, JAMES;WANG, YAPING;ZHAO, QIAN |
分类号 |
C07D413/14;A61K31/506;A61P35/00;C07D413/04;C07D417/14 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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