| 摘要 |
This invention relates to a solid oral dosage form containing one or more pharmaceutically active ingredients solubilised or suspended in a pharmaceutically acceptable solvent or liquid phase and encapsulated in seamless controlled release microcapsules. Accordingly the pharmaceutically acceptable solvent or liquid phase may range from aqueous phase, organic solvent(s), glycols, oils and derivatives thereof, for example mono-, di, and trigycerides of short, medium and long chain fatty acids. The invention also relates to a process of seamless microcapsule formation wherein two different solutions, which are not dissolved with each other or are hardly dissolved with each other, contact each other. The solutions are a core solution which is a hydrophobic solution or suspension of an active ingredient and a shell solution. In the process, a shell/core mixed suspension is processed through a nozzle having a single orifice, to form a capsule or a bead of shell/core mixed suspension which is then ejected into a cooling or hardening solution and wherein the shell solution is gelled or solidified. |
