COMPOSITIONS AND METHODS OF TREATING PULMONARY HYPERTENSION

摘要

Provided are formulations comprising therapeutically effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and tadalafil or a pharmaceutically acceptable salt thereof and methods of treating and/or preventing pulmonary hypertension by administration of the formulations.

主权项

1. A combination therapy comprising:
a therapeutically effective amount of a selective type-A endothelin receptor antagonist (ERA) selected from the group consisting of ambrisentan, sitaxsentan and pharmaceutically acceptable salts thereof, and a therapeutically effective amount of a phosphodiesterase type 5 (PDE5) inhibitor selected from the group consisting of sildenafil, tadalafil, vardenafil and pharmaceutically acceptable salts thereof, wherein the weight ratio of the selective type-A ERA and the PDE5 inhibitor is in a range from about 1:1 to about 1:10.