Implantable Devices with Delivery Systems and Methods for Blocking Digestive Neurohormonal Pathways in Mammals

摘要

Described herein are implantable devices, delivery systems and surgical methods for creating a barrier that may be deployed into a digestive system organ to block the biochemical and/or neurohormonal systems thereby providing therapeutic benefit ideally treating diabetes mellitus and obesity. The device for creating a barrier in the digestive system organ may include a wall or conduit whether impermeable or porous at varying degrees. Method of surgical delivery for the device described herein may be conducted through open, laparoscopic, minimally invasive, or endoscopic means. The device may be temporarily secured on a novel delivery system enabling the methods described. The device may be secured to the digestive organ allowing natural biomechanical motion (peristaltic motion) of the digestive system without untoward effects.

主权项

1. A conduit for implantation into a gastrointestinal tract of a subject, comprising:
a substantially flexible, elongated tubular body having a longitudinally-extending central lumen, a proximal end and a distal end; a first tubular cuff connected to the proximal end, the first tubular cuff including a first cuff opening extending through the first tubular cuff and in fluid communication with the longitudinally-extending central lumen of the tubular body, the first tubular cuff being sized and configured to fit within a first location within the gastrointestinal tract of the subject; a second tubular cuff connected to the distal end, the second tubular cuff including a second cuff opening extending through the first tubular cuff and in fluid communication with the longitudinally-extending central lumen of the tubular body, the second tubular cuff being sized and configured to fit within a second location within the gastrointestinal tract of the subject; a wall of the substantially flexible, elongated tubular body comprising an inner layer of flexible, substantially nonporous material and an outer layer of flexible, substantially porous material; and the outer layer of substantially porous material impregnated with a therapeutic constituent.