SYNERGISTIC ENHANCEMENT OF THE DELIVERY OF NUCLEIC ACIDS VIA BLENDED FORMULATIONS
摘要
Disclosed herein are pharmaceutical compositions that comprise "blends" of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
申请公布号
WO2014144196(A1)
申请公布日期
2014.09.18
申请号
WO2014US28498
申请日期
2014.03.14
申请人
SHIRE HUMAN GENETIC THERAPIES, INC.
发明人
DEROSA, FRANK;SMITH, LIANNE;HEARTLEIN, MICHAEL;GUILD, BRAYDON CHARLES