METHODS FOR DETERMINING VIRAL SENSITIVITY TO VIRAL INHIBITORS

摘要

Methods and compositions for the efficient and accurate determination of susceptibility of a hepatitis C virus (HCV) or HCV population to an HCV inhibitor. The inhibitor may include, for example, an interferon (IFN), ribavirin (RBV), one or more nucleos(t)ide inhibitors, including for example nucleoside inhibitor-1 (NI-1), 2′C-methyl adenosine (2′CMeA), sofosbuvir (SOF), or non-nucleoside inhibitor targeting site A or B (NNI-A or NNI-B) are provided. The methods may involve determining the genotype of the HCV or the phenotype of the HCV with respect to the inhibitor susceptibility. The methods may further include the selection of a suitable treatment based on the genotype or phenotype determined.

主权项

1. A method for selecting a treatment for a patient having a hepatitis C virus (HCV) infection, comprising:
(a) obtaining a biological sample from the patient, wherein the biological sample comprises an HCV or HCV population from the patient; (b) determining the genotype of the HCV or HCV population; and (c) treating the patient with ribavirin or a nucleoside inhibitor if the HCV or HCV population comprises a genotype 2 (GT2) HCV, genotype 3 (GT3) HCV, genotype 4 (GT4) HCV, or a combination thereof.