COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR PSORIASIS

摘要

The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject.

主权项

1. A method for diagnosing and/or prognosing of psoriasis comprising the steps of:
(i) determining an expression profile of a set comprising at least two miRNAs representative thr psoriasis in a blood sample from a subject, and (ii) comparing said expression profile to a reference, wherein the comparison of said expression profile to said reference allows for the diagnosis and/or prognosis of psoriasis, wherein the nucleotide sequences of the miRNAs comprised in the set are selected from the group consisting of SEQ ID NO 1 to 283, a fragment thereof, and a sequence having at least 80% sequence identity thereto.