发明名称 |
Crystalline monohydrate of epirubicin hydrochloride |
摘要 |
<p>The present invention relates to a crystalline monohydrate of epirubicin hydrochloride having water content in the range between 2.7% and 3.5% (w/w) and being devoid of residual solvents as well as to a corresponding method for its production. The method comprises: (a) adding at least a first solvent and at least a second solvent to epirubicin hydrochloride, wherein the first solvent is a linear or branched C 4 to C 5 alcohol, and the second solvent is a linear or branched C 2 to C 3 alcohol; (b) adjusting in the solution obtained the water content to an amount in the range between 7% and 12% (w/w); and (c) heating the mixture to a temperature of 70°C to 90°C in order to allow crystallization.</p> |
申请公布号 |
EP2778171(A1) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20130159392 |
申请日期 |
2013.03.15 |
申请人 |
SYNBIAS PHARMA LTD. |
发明人 |
ZABUDKIN, ALEXANDER;MATVYEYEV, ALEXEY;MATVIENKO, VICTOR |
分类号 |
C07H15/252 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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