Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia

摘要

The present invention relates to a method of identifying a compound involved in pain, the use of Ctla2b nucleic acid or Ctla2b protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same.

主权项

1. A method for identifying a compound involved in neuropathic pain comprising the steps of:
a) providing a cell-based system comprising a cytotoxic T lymphocyte-associated protein 2 beta (Ctla2b) nucleic acid encoding a protein comprising the amino acid sequence of either SEQ ID NO: 1 or 2, b) contacting the cell-based system with a test compound, and c) determining an effect of the test compound on the cell-based system, wherein the test compound is identified as a compound involved in neuropathic pain when the test compound causes a statistically significant increase in the level of Ctla2b nucleic acid encoding a protein comprising the amino acid sequence of either SEQ ID NO: 1 or 2 relative to the same cell-based system that was not contacted with the test compound.