| 摘要 |
The present invention provides a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment of cancer in a subject comprising administering to said subject an effective amount of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is the use of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof in the preparation of a medicament for the treatment of cancer. In addition, the present invention also provides a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof.; |
| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein:E and G are each independently selected from the group consisting of C1-4alkyl, —NH—, —N(C1-4alkyl)-, —O— and, in either orientation, —NH—C1-4alkyl-, —N(C1-4alkyl)-C1-4alkyl-, and —O—C1-4alkyl-; and
is a single bond;
when is a single bond, K is independently selected from CH and N, and J is independently selected from NH and CH2; orR1 and R2 are each 0-2 substituents wherein each substituent is independently selected from the group consisting of —C1-4alkyl, —OH, —O—C1-4alkyl, N(R4)2, C1-4alkylN(R4)2, NO2, halogen, and CF3;
each R4 is independently selected from the group consisting of H, OH, —C1-4alkyl, —C(O)OC1-4alkyl, and —C(O)R5, provided that if one R4 is OH then the other R4 cannot be OH; or —N(R4)2 forms a pyrrolidinyl, piperidinyl, piperazinyl, or morpholino group optionally substituted methyl; R5 is selected from the group consisting of —C1-4alkyl and phenyl; and R3 is selected from the group consisting of H, —C1-4alkyl, aryl, and alkylaryl. |
