主权项 |
1. A compound of Formula 1,or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from C3-8 cycloalkyl, C2-6 heterocyclyl, C6-14 aryl, and C1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, R11, and R12; R2, R4, and R5 are each independently selected from hydrogen, halo, —OH, —CN, C1-3 alkyl, and C1-3 haloalkyl; R3 is selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl; R6 and R7 are each independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl; R8 is selected from hydrogen, methyl, and —NH2; R9 is selected from hydrogen, halo, —CN, C1-3 haloalkyl, —OR16, —C(O)R16, —C(O)OR16, —C(O)N(R16)R17, —C(O)N(R16)OR17, —C(O)N(R16)S(O)2R18, SR16, —S(O)R18, —S(O)2R18, and —S(O)2N(R16)R17; or R8 is selected from —NH— and —CH2—, and R8 and R9, together with the carbon atoms to which they are attached, form a C2-4 heteroarylene having 5 ring atoms and 1 to 3 heteroatoms, each of the heteroatoms being nitrogen, and wherein the C2-4 heteroarylene is optionally substituted with R12; R10 is selected from halo, —OH, C1-3 alkyl, —NHR16, and —NHC(O)R16; each R11 is independently selected from —OR13, —N(R13)R14, —NR13C(O)R14, —NHC(O)NR13R14, —NR13C(O)NHR14, —C(O)R13, —C(O)OR13, —C(O)N(R13)R14, —C(O)N(R13)OR14, —C(O)N(R13)S(O)2R12, —N(R13)S(O)2R12, —SR13, —S(O)R12, —S(O)2R12, and —S(O)2N(R13)R14; each R12 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl-(CH2)m—, C6-14 aryl-(CH2)m—, C2-6 heterocyclyl-(CH2)m—, and C1-9 heteroaryl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, C1-6 alkyl, C1-6 haloalkyl, and R15; each R13 and R14 is independently selected from
(a) hydrogen; and(b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl-(CH2)m—, C6-14 aryl-(CH2)m—, C2-6 heterocyclyl-(CH2)m—, and C1-9 heteroaryl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, C1-6 alkyl, C1-6 haloalkyl, and R15; each R15 is independently selected from −OR16, —N(R16)R17, —N(R16)C(O)R17, —NHC(O)NR16R17, —NR16C(O)NHR17, —C(O)R16, —C(O)OR16, —C(O)N(R16)R17, —C(O)N(R16)OR17, —C(O)N(R16)S(O)2R18, —NR16S(O)2R18, —SR16, —S(O)R18, —S(O)2R18, and —S(O)2N(R16)R17; each R16 and R17 is independently selected from hydrogen, C1-6 alkyl, and C3-6 cycloalkyl; each R18 is independently selected from C1-6 alkyl and C3-6 cycloalkyl; each m is independently selected from 0, 1, 2, 3, and 4; wherein each of the aforementioned heteroaryl moieties independently has 1 to 4 heteroatoms independently selected from N, O, and S, and each of the aforementioned heterocyclyl moieties independently has 1 to 4 heteroatoms independently selected from N, O, and S. |