发明名称 |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
摘要 |
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression. |
申请公布号 |
US8835623(B2) |
申请公布日期 |
2014.09.16 |
申请号 |
US201313937412 |
申请日期 |
2013.08.06 |
申请人 |
Sirna Therapeutics, Inc. |
发明人 |
Brown Duncan;Cunningham James J.;Gindy Marian;Pickering Victoria;Stanton Matthew G.;Stirdivant Steven M.;Strapps Walter R. |
分类号 |
C07H21/02;C07H21/04 |
主分类号 |
C07H21/02 |
代理机构 |
McCarter & English, LLP |
代理人 |
McCarter & English, LLP ;Zacharakis Maria Laccotripe;Nagle Deborah L. |
主权项 |
1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits the expression of cadherin-associated protein, beta 1 (CTNNB1), wherein the siNA comprises:
5′-CUGUUGGAUUGAUUCGAAA-3′ (SEQ ID NO: 5) and 5′-UUUCGAAUCAAUCCAACAG-3′ (SEQ ID NO: 4918). |
地址 |
Cambridge MA US |