COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

摘要

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

主权项

1. A compound having the structure of Formula (I):wherein:
A is X is CH or N; R1 is C1 or CH3; each R2 is independently selected from halogen, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, and phenyl; R3 is C1-C6alkyl, C1-C6haloalkyl, or C3-C8cycloalkyl; m is an integer selected from 0-3; n is an integer selected from 0-2; p is an integer selected from 1-2; or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.