Methods for Evaluating Regional Cardiac Function and Dyssynchrony from a Dynamic Imaging Modality Using Endocardial Motion

摘要

An embodiment in accordance with the present invention provides a method and system for evaluating regional cardiac function and dyssynchrony from an imaging modality using the motion of endocardial features of the heart. In the method and system, an imaging modality such as a CT scanner is used to obtain an image sequence that is then processed using a computer program. The computer program is configured to create an endocardial mesh formed from triangular components that represents at least the region of interest of the subject's heart. From tracking the motion of conserved topological features on this endocardial mesh at least two time points a displacement map can be modeled. The displacement map can be further analyzed to determine metrics of regional cardiac function such as SQUEEZ, myocardial strain, torsion etc., and the displacement map can also be used to create visual representations of the function of the subject's heart.

主权项

1. A method for assessment of function of a region of interest of a subject's heart comprising:
acquiring an image sequence for the region of interest of the subject's heart using an imaging modality; inputting the image sequence into a processor configured to execute steps comprising: determining a binary volume for each image of the image sequence; creating a triangular mesh representing an endocardial boundary for the region of interest of the subject's heart; calculating a quantitative map describing local geometric features of the mesh; using the quantitative map along with coordinates of the region of interest of the subject's heart in a nonrigid registration algorithm to track local features through time to obtain a displacement map of the region of interest; using the displacement map to calculate trajectories of individual points on the region of interest of the subject's heart to obtain a mesh having corresponding triangular elements; calculating a function of the ratio of areas of the corresponding triangular elements; and making a determination of cardiac function.