| 发明名称 |
METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL |
| 摘要 |
Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed. |
| 申请公布号 |
US2014255359(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201214352410 |
申请日期 |
2012.10.17 |
| 申请人 |
STOWERS INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
Perry John M.;Li Linheng;Venkatraman Aparna;He Xi |
| 分类号 |
C12N5/0789;A61K35/28 |
主分类号 |
C12N5/0789 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An ex vivo method for expanding the number of hematopoietic stem cells (HSC) in a population of mononuclear cells (MNC) comprising culturing the population of MNCs comprising at least one HSC in an HSC expansion media for a period of time sufficient to expand the number of HSCs in the MNC population, wherein the HSC expansion media comprises a modulator of DNA methyltransferase (DNMT) and a modulator of the Wnt pathway. |
| 地址 |
Kansas City MO US |
