| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a small-molecular mimic of Smac peptide, which is a dimer or dimer-like compound.SOLUTION: A dimer or dimer-like compound has two structurally similar binding regions and a pharmaceutical composition comprises them. These compounds are useful for facilitating apoptosis and a method of treating a cancer and a condition such as autoimmune disorders includes using them. [Each of Y and Y' is C1-C8 alkyl or the like which may be independently substituted; R, R, R' and R' are each independently H or C1-C8 alkyl or the like; each of Rand R' is independently H or C1-C8 alkyl or the like; J and J' are each independently -C(O)- or the like; each R' is independently H or the like; each p is independently 2 to 4; n and n' are independently 0 to 3; m and m' are independently 0 to 4; and Z and Z' are independently a C1-C6 aminoalkyl group which may be substituted.]</p> |
