| 发明名称 |
Method of Treating Rheumatoid Arthritis With An Anti-IL-6R Antibody |
| 摘要 |
The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. |
| 申请公布号 |
US2014255390(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201314020573 |
申请日期 |
2013.09.06 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
Radin Allen;Stevens Sean;Huang Tammy T.;Martin Joel H.;Fairhurst Jeanette L.;Rafique Ashique;Smith Eric;Pobursky Kevin J.;Papadopoulos Nicholas J.;Fandl James P.;Chen Gang;Karow Margaret |
| 分类号 |
A61K39/395;A61K31/519;A61K45/06;C07K16/24 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating rheumatoid arthritis (RA) in a subject, comprising:
administering to the subject a therapeutically effective amount of a human antibody or antigen-binding fragment thereof which specifically binds to human interleukin-6 (hIL-6R) with a KD of about 500 pM or less as measured by surface plasmon resonance. |
| 地址 |
Tarrytown NY US |
