| 摘要 |
The present invention provides a method for detecting ACF by analyzing a test region of large intestine tissue at the molecular level. Namely, the present invention relates to a method for detecting aberrant crypt foci (ACF) that comprises detecting an ACF detection marker in a test region of large intestine tissue, by using one or more types of molecules for which ACF-specific expression increases as the ACF detection marker, the molecule being selected from the group consisting of Met, Cdh1, Ctnnb1, and GSTp; an ACF detection marker for detecting the ACF in human-derived large intestine tissue, that is Met, Cdh1, Ctnnb1, or GSTp; and, a method for evaluating risk of colorectal cancer and colorectal adenoma in human subjects based on the results of detecting ACF in a test region of large intestine tissue of the subjects using the aforementioned ACF detection method. |
| 主权项 |
1. A method for detecting aberrant crypt foci (ACF), comprising:
detecting an ACF detection marker in a test region of large intestine tissue, by using one or more types of molecules for which ACF-specific expression increases as the ACF detection marker, the molecules being selected from the group consisting of Met, Cdh1, Ctnnb1, and GSTp. |
