DECARBOXYLATION DOSIMETRY

摘要

Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure. The reactants include carboxyl acids, such as amino acids and others occurring naturally in mammals. The dosimetry may be performed in real-time or retrospectively by assaying a sample of tissue from a patient. Also disclosed is a device which detects and measures radiation dosages based on decarboxylation of a reactant contained therein.

主权项

1. A method of determining an effect of ionizing radiation, comprising:
allowing a sample comprising a carboxylic acid to be exposed to an initially unknown amount of ionizing radiation, such that a single-electron oxidized product and carbon dioxide are produced from the carboxylic acid; exposing the single-electron oxidized product to a radioprotectant, such that the single-electron oxidized product form an end product; determining an amount of the end product; and based on the amount of the end product, determining the amount of ionizing radiation.