发明名称 |
ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF |
摘要 |
The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis. |
申请公布号 |
US2014256635(A1) |
申请公布日期 |
2014.09.11 |
申请号 |
US201414202682 |
申请日期 |
2014.03.10 |
申请人 |
Northwestern University |
发明人 |
Zha Runye H.;Zhang Ming;Stupp Samuel I. |
分类号 |
C07K14/81 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
1. A composition, the composition comprising: (a) a hydrophobic tail; (b) a peptide sequence capable of beta-sheet formation; and (c) a peptide configured to inhibit angiogenesis. |
地址 |
Evanston IL US |