COMBINATION OF A NANOPARTICLE COMPRISING A CHARGED CORE MADE OF PHOSPHOLIPID WITH A PROTEIN - USE FOR THE IN VITRO DELIVERY OF SAID PROTEIN

摘要

The present invention relates to a nanoparticle comprising (a) a solid and porous core formed from a polymer obtained by reaction between a maltodextrin and an epoxide compound, wherein quaternary ammonium functions are grafted onto said polymer in order to confer on said polymer the positive charge thereof, and (b) a lipid with a negative ionic charge, contained in said core. According to the invention, said nanoparticle comprises a protein or a protein fragment adsorbed onto said core. The present invention also relates to the use of said nanoparticle for the delivery of said protein or of said protein fragment into the cytosol of a cell.