发明名称 |
Self-assembling peptides incorporating modifications and methods of use thereof |
摘要 |
<p>The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.
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申请公布号 |
EP2711025(A3) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20130169926 |
申请日期 |
2004.06.25 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
SEMINO, CARLOS;ZHANG, SHUGUANG;GENOVE, ELSA |
分类号 |
A61K47/48;A61K38/00;A61L27/38;C07K;C07K7/06;C07K7/08;C07K14/39;C07K14/78;C12N5/00;C12N5/071 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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