| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a new compound of formula[I] or to its pharmaceutically acceptable salt, wherein A represents optionally substituted alkyl, wherein the substitute represents identical or different 1-3 groups specified in aryl optionally substituted by 1-3 groups specified in alkyl, halogen, alkoxy and alkanoyl; cycloalkyl optionally substituted by 1-3 groups specified in alkyl and halogen; hydroxy; alkoxy; halogen; an amino group and oxo; an optionally substituted carbocyclic group specified in a mono- and bicyclic group, wherein an aromatic ring and cycloalkyl are condensed; optionally substituted aryl, an optionally substituted completely saturated 5- or 6-merous monocyclic heterocyclic group each of which contains 1 heteroatom specified in nitrogen and oxygen, wherein the substitute of optionally substituted aryl, the optionally substituted carbocyclic group and the optionally substituted heterocyclic group for A represents identical or different 1-3 groups specified in alkyl, optionally substituted hydroxy, alkoxy, cycloalkyl or halogen; cycloalkyl optionally substituted by alkyl or alkoxy; alkoxy optionally substituted by halogen; halogen; hydroxy; oxo; heterocycle; alkyl sulphonyl; and mono- or dialkylcarbamoyl, optionally substituted amino, wherein the substitute represents identical or different 1 or 2 alkyl or aryl, or optionally substituted carbamoyl, wherein the substitute represents identical or different 1 or 2 alkyls optionally substituted by aryl, X represents optionally substituted methylene or -O-, wherein the substitute of optionally substituted methylene for X represents alkoxy or hydroxy, Q represents N or C-R, Lrepresents a single bond, methylene, -CH=CH-, -O-, -CO-, -NR-, -NRCO-, -CONR- or -CHNR-, Lrepresents a single bond, -CRR- or a bivalent 5- or 6-merous completely saturated monocyclic heterocyclic group each of which contains 1 heteroatom specified in nitrogen and oxygen, Rand Rare identical or different, and each represents hydrogen, alkyl or halogen, Rand Rare identical or different, and each represents hydrogen, alkyl, alkoxy, cyano or halogen, Rand Rare optionally bond thereby forming 5- or 6-merous cycloalkane, or a 5- or 6-merous aliphatic heterocycle containing oxygen atom, Rrepresents a carboxyl group, an alkoxycarbonyl group or a bioisosteric group of the carboxyl group, Rand Rare identical or different, and each represents hydrogen or alkyl, or Rand Rare bond thereby forming cycloalkane, Rrepresents hydroxy, alkanoylamino or alkyl sulphonylamino, Rand Rrepresent hydrogen or halogen, and Rrepresents hydrogen or alkyl. Besides, the invention refers to specific compounds of formula [I], a drug based on the compound of formula [I], using the compound of formula [I], a method of treating based on using the compound of formula [I], and an intermediate compound of formula[II].EFFECT: there are prepared new compounds possessing the agonist activity on thyroid hormone ? receptor.18 cl, 36 tbl, 344 ex |
