| 摘要 |
The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.; |
| 主权项 |
1. A method for treating multiple myeloma comprising administering to a patient in need of such treatment an effective amount of a compound of Formula II: or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein: R1 is selected from —NH—CO-alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; X represents CH or N; R2a is selected from —H, —OH, alkyl, alkoxy, haloalkyl, aminoalkyl, hydroxyalkyl, halo, amino and benzoate; R2b is selected from —H and alkyl; R3 is selected from H, OH, alkyl, alkoxy and halo; R4a is selected from —OH, alkyl, alkoxy, haloalkyl, aminoalkyl, hydroxyalkyl, halo and amino; and R4b is selected from H, alkyl and halo. |
