| 发明名称 | Recombinant attenuated dengue viruses comprising a deletion in the 3′ untranslated region and additional attenuating mutations induced by chemical mutagenesis | ||
| 摘要 | The invention provides compositions featuring an attenuated dengue virus mutant or an attenuated chimeric dengue virus mutant. | ||
| 申请公布号 | USRE45123(E1) | 申请公布日期 | 2014.09.09 |
| 申请号 | US201313896409 | 申请日期 | 2013.05.17 |
| 申请人 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | 发明人 | Whitehead Stephen S.;Murphy Brian R.;Hanley Kathryn A.;Blaney Joseph E.;Lai Ching-Juh |
| 分类号 | A61K39/12;C12N7/04 | 主分类号 | A61K39/12 |
| 代理机构 | Edwards Wildman Palmer LLP | 代理人 | Edwards Wildman Palmer LLP ;Corless Peter F.;Emmons Richard B. |
| 主权项 | 1. An immunogenic composition comprising an attenuated dengue virus or attenuated chimeric dengue virus comprising (a) a nucleic acid encoding a structural protein from dengue serotype 1, dengue serotype 2, dengue serotype 3, or dengue serotype 4; and (b) a nucleic acid comprising remaining coding and non-coding regions of a dengue serotype 4 virus (DEN4 backbone), wherein the DEN4 backbone comprises a 30 nucleotide deletion in the 3′ untranslated region corresponding to nucleotides 172-143 (DEN4Δ30 backbone), wherein the numbering is based upon a prototypic DEN4 Dominica 1981 isolate, and wherein the DEN4 backbone further comprises one or more mutations from Table 37. | ||
| 地址 | Washington DC US | ||