SPRAY-DRIED PHARMACEUTICAL COMPOSITIONS COMPRISING ACTIVE AGENT NANOPARTICLES

摘要

Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 μm, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 μm; at least 50% of the spray-dried particles have a particle size of at least about 15 μm; and at least 90% of the spray-dried particles have a particle size of up to about 55 μm. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally administering the compositions, such as intranasally or intravaginally.

主权项

1. A dry pharmaceutical composition for transmucosal administration, comprising spray-dried particles comprising pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, wherein
the active agent nanoparticles have an average particle size diameter of less than about 1 μm; up to 10% of the spray-dried particles have a particle size of less than 10 μm, at least 50% of the spray-dried particles have a particle size of at least about 15 μm, and at least 90% of the spray-dried particles have a particle size of up to about 55 μm.