METHODS AND COMPOSITIONS FOR ENHANCING AN IMMUNE RESPONSE, BLOCKING MONOCYTE MIGRATION, AMPLIFYING VACCINE IMMUNITY AND INHIBITING TUMOR GROWTH AND METASTASIS

摘要

Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided.

主权项

1. A method of enhancing an immune response against an antigen in an individual, the method comprising administering to the individual an effective amount of the antigen in conjunction with a compound of Formula (I) wherein R1 is hydrogen or C1-6 alkyl; is a single bond or double bond; Q1 is N or CH; R2 is selected from hydrogen and C1-6 alkylene, wherein one carbon unit of said alkylene is optionally replaced with —O—, —S—, —SO—, —SO2—, —NRa—, or —CO—; wherein Ra is hydrogen or C1-6 alkyl; and R3 is hydrogen or an optionally substituted 5-membered heteroaryl ring; wherein the heteroaryl ring is optionally substituted with C1-6alkyl; or pharmaceutically acceptable salts thereof.