发明名称 |
HUMANIZED ANTI-EPIREGULIN ANTIBODY, AND CANCER THERAPEUTIC AGENT COMPRISING SAID ANTIBODY AS ACTIVE INGREDIENT |
摘要 |
The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue substitutions in the variable-region sequences of the humanized EP27 antibody which inhibits growth of cancer cells by exhibiting cytotoxic activity and neutralizing activity against anti-human Epiregulin-expressing cancer cells. |
申请公布号 |
KR20140107610(A) |
申请公布日期 |
2014.09.04 |
申请号 |
KR20147020786 |
申请日期 |
2012.12.28 |
申请人 |
CHUGAI SEIYAKU KABUSHIKIKAISHA |
发明人 |
SHIRAIWA HIROTAKE;ESAKI KEIKO;IGAWA TOMOYUKI;KURAMOCHI TAICHI;MAEDA ATSUHIKO;TAMBA SHIGERO;TSUNODA HIROYUKI;TACHIBANA TATSUHIKO;KINOSHITA YASUKO;SUZUKI MASAMI;KATO ATSUHIKO;TAKEIRI ETSUKO;HASHIMOTO ERI;WATANABE YOSHINORI |
分类号 |
C07K16/46;A61K39/395;A61P35/00;C07K16/22;C12N15/13;C12P21/08 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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