Dosage of oligonucleotides suitable for the treatment of tumors

摘要

A method for preventing and/or treating a tumor, the method comprising: intravenously administering an antisense oligonucleotide in an amount of between about 400 to about 800 mg/m2/treatment cycle, the antisense oligonucleotide comprises 8 to 30 nucleotide building blocks, which hybridizes with mRNA of TGF-beta-2, -1 and/or -3 for the preparation of a pharmaceutical composition.

主权项

1. A method for treating pancreatic carcinoma or malignant melanoma consisting of: intravenously administering only an antisense oligonucleotide of sequence SEQ ID NO: 22 in an amount of between about 400 to about 800 mg/m2/treatment cycle, wherein a treatment cycle consists of an administration cycle that is the time taken for a first administration of about 400 to about 800 mg/m2 of the oligonucleotide, and, if any further administration cycle is performed, the time interval between consecutive administration cycles.