2-pyridone compounds

摘要

A 2-pyridone compound represented by the formula [1]:;
{wherein in the formula [1],

the ring represented by A represents a benzene ring or a pyridine ring,

X represents any of the structures represented by the formulas [3] shown below:
;
V represents a single bond or a lower alkylene group, and

W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)},

a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

主权项

1. A 2-pyridone compound represented by the formula [1]: wherein in the formula [1], the ring represented by A represents a benzene ring; R1 represents RA—ZA—, wherein —ZA— represents a single bond or represents any of the following formulas [2]: when —ZA— represents any of the formulas [2], RA represents a lower alkyl group, a lower cycloalkyl group or a phenyl group (wherein the lower alkyl group, lower cycloalkyl group or phenyl group is unsubstituted or substituted with 1 to 3 groups which may be the same or different and selected from the following Substituent Group A1), or when —ZA— represents a single bond, RA represents a lower alkyl group, a lower cycloalkyl group or a phenyl group (wherein the lower alkyl group, lower cycloalkyl group or phenyl group is unsubstituted or substituted with 1 to 3 groups which may be the same or different and selected from the following Substituent Group A1), a hydrogen atom, a cyano group, a halogen atom, a hydroxy group, an amino group, a carbamoyl group, a sulfamoyl group or a ureido group, RZ1 and RZ2 are the same or different and each represent a hydrogen atom or a lower alkyl group; X represents any of the structures represented by the formulas [3] shown below: RX represents a hydrogen atom, RY1 and RY2 each represent a hydrogen atom; R4 represents RB—ZB—, wherein —ZB— represents a single bond, and RB represents an oxopyrrolidinyl group, Substituent Group A1 represents a halogen atom, a lower cycloalkyl group, a phenyl group, a hydroxy group, a lower alkoxy group, a mono-lower alkylamino group, a di-lower alkylamino group or a lower alkylsulfonyl group; R2 and R3 are the same or different and each represent a hydrogen atom, a halogen atom, a cyano group, a carbamoyl group, a lower alkyl group, a lower alkylsulfonyl group, a lower cycloalkyl group, a lower alkoxy group, a lower cycloalkoxy group (wherein the lower alkyl group, lower alkylsulfonyl group, lower cycloalkyl group, lower alkoxy group or lower cycloalkoxy group is unsubstituted or substituted with 1 to 3 halogen atoms) or a hydroxy group, or the adjacent R1 and R2 together form a naphthalene ring together with the benzene ring; R5 represents a halogen atom, a carbamoyl group, a lower alkanoyl group, an amino group, a di-lower alkylamino group, a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, a lower cycloalkoxy group, a phenyl group or a phenoxy group (wherein the lower alkyl group, lower cycloalkyl group, lower alkoxy group, lower cycloalkoxy group, phenyl group or phenoxy group is unsubstituted or substituted with 1 to 3 groups which may be the same or different and selected from the following Substituent Group A3), Substituent Group A3 represents a halogen atom, a hydroxy group, a lower alkyl group (wherein the lower alkyl group is unsubstituted or substituted with 1 to 3 halogen atoms), a lower cycloalkyl group, a phenyl group, a di-lower alkylamino group or a carbamoyl group; V represents a single bond, and W represents a single bond, a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof.