| 摘要 |
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation. |
| 主权项 |
1. A method of mitigating or treating radiation injury in a subject, or providing radioprotection to a subject, comprising administering to the subject prior to, during or after exposure of the subject to radiation, a composition comprising an amount of a targeted nitroxide compound effective to mitigate or treat radiation injury in the subject, or provide radioprotection to the subject; wherein the targeted nitroxide compound has the structurewherein X is one of R1, and R2 are hydrogen, or a C1-C6 straight or branched-chain alkyl; R4 is hydrogen, C1-C6 straight or branched-chain alkyl, or a C1-C6 straight or branched-chain alkyl further comprising a phenyl (C6H5) group, that is unsubstituted or is methyl-, hydroxyl- or fluoro-substituted; R3 is —NH—R5, —O—R5 or —CH2—R5, and R5 is an —N—O., —N—OH or N═O containing group; R is —C(O)—R6, —C(O)O—R6, or —P(O)—(R6)2, wherein R6 is C1—C6 straight or branched-chain alkyl or C1—C6 straight or branched-chain alkyl further comprising one or more phenyl (—C6H5) groups that are independently unsubstituted, or methyl-, ethyl-, hydroxyl- or fluoro-substituted. |
