| 发明名称 |
Dual-acting pyrazole antihypertensive agents |
| 摘要 |
In one aspect, the invention relates to compounds having the formula:;
wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. |
| 申请公布号 |
US8822522(B2) |
申请公布日期 |
2014.09.02 |
| 申请号 |
US201213685128 |
申请日期 |
2012.11.26 |
| 申请人 |
Theravance Biopharma R&D IP, LLC |
发明人 |
Blair Brooke;Fatheree Paul R.;Fleury Melissa;Gendron Roland;Hudson Ryan;McKinnell Robert Murray;Wilson Michael |
| 分类号 |
C07D231/10;A61K31/415;C07D403/10;C07D405/14;C07D403/14;C07D401/14;C07D231/14;C07D231/12;C07D413/10;C07D409/14;C07D403/06;C07D401/06 |
主分类号 |
C07D231/10 |
| 代理机构 |
|
代理人 |
Hagenah Jeffrey A.;Eberle Shelley |
| 主权项 |
1. A compound of formula: where: R is 3-fluoro, R3 is propyl, R4 is —CH2SH, and R5 is i-butyl; or a pharmaceutically acceptable salt thereof. |
| 地址 |
South San Francisco CA US |
