| 摘要 |
Disclosed are pyrazolospiroketone derivatives for use as acetyl-CoA carboxylase inhibitors of general Formula (I) wherein the substituents are as described in the specification. Also disclosed is the use of the compounds in manufacturing a medicament for treating obesity and obesity related diseases such as Type 2 diabetes by inhibiting fatty acid synthesis and by increasing fatty acid oxidation. Examples of the compounds of formula (I) are: 6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1’H-spiro[indazole-5,4’-piperidin]-1’-yl)carbonyl]-1H-indole-3-carboxamide and; 1’-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-1-isopropyl-1,4-dihydrospiro[indazole-5,4’piperidin]-7(6H)-one and; 5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1’H-spiro[indazole-5,4’-piperidin]-1’-yl)carbonyl]-1H-indazole-3-carboxamide |
