| 摘要 |
Provided herein are compounds of the formula (I) or (II) wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as antagonist of interactions between p53 and MDM2 which is useful in the treatment of cancer. In one embodiment the compound is (2’S,3’R,4’S,5’R)-6-chloro-4’-(3-chloro-2-fluoro-phenyl)-2’-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3’-pyrrolidine]-5’-carboxylic acid [4-(2-hydroxy-ethoxy)-phenyl]-amide. |
