Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen

摘要

Provided are sodium ibuprofen compositions and methods of manufacturing tablets and caplets comprising sodium ibuprofen. The compositions are advantageous because they allow for the formation of tablets having low sodium content and further provide tablets exhibiting improved physical stability, high tablet hardness and high strength, coupled with excellent dissolution and bioavailability characteristics. The compositions and processes are further advantageous because tablets can be produced in large quantities without an unacceptable number of defective tablets. In one embodiment the composition comprises a core comprising sodium ibuprofen dihydrate.