9 &Bgr;-HALOGENATED PROSTAGLANDIN COMPOUNDS AND PROCESSES FOR PREPARING THE SAME

摘要

The invention relates to 9β-halogenated prostaglandin compounds and to processes for preparing the same. The claimed compounds have the formula II, wherein X is halogen, Y is an alkyl group with 1...12 carbon atoms, Z is a (non)-substituted C-C saturated, double or triple, methylene group, R, Rare oxygen or Ris hydrogen, and Ris hydroxyl or ether and vice-versa, Ris a (non)-substituted hydroxyl, cyan, ester, amide group. The claimed process consists in reacting some halogenatedδ-lactone intermediates with the reagents of formula HO-Y-Rin acid catalysis, in the presence of an inert solvent or an inert solvent mixture.