发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF POMPE DISEASE |
摘要 |
<p>Provided herein are chimeric polypeptides comprising a mature acid-alpha glucosidase (GAA) polypeptide and an internalizing moiety. An exemplary internalizing moiety of the application is the 3E10 antibody which is capable of transiting a cellular membrane via an equilibrative nucleoside transporter 2 (ENT2) and binding DNA. Further provided are methods and uses of the said chimeric polypetides for treating Pompe disease, increasing acid alpha-glucosidase enzyme activity in a cell and decreasing glycogen accumulation in the cytoplasm, lysosomes and autophagic vacuoles of cells.</p> |
申请公布号 |
CA2901978(A1) |
申请公布日期 |
2014.08.28 |
申请号 |
CA20142901978 |
申请日期 |
2014.02.20 |
申请人 |
VALERION THERAPEUTICS, LLC |
发明人 |
ARMSTRONG, DUSTIN D.;WAY, JEFFREY C. |
分类号 |
C07K14/47;A61K38/47;A61K39/395;A61P43/00;C07K19/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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