FURYL AND THIENYL TRIAZOLE DERIVATIVES AND THERAPEUTIC USES THEREOF

摘要

Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH═CH-thienyl and optionally substituted provided that R2 is substituted with as nitro group;;Treatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.

主权项

1. A method of treating an infection in a human or an animal, comprising administering a therapeutically effective amount of at least one compound of Formula (3) or Formula (4), wherein R1 and for R2 are independently selected from the group consisting of optionally substituted thienyl, optionally substituted furyl, optionally substituted aryl, optionally substituted —CH═CH-thienyl, optionally substituted −CH═CH-furyl and optionally substituted —CH═CH-aryl, provided that at least one of R1 and R2 is optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH═CH-thienyl, or optionally substituted —CH═CH-furyl