| 摘要 |
Diphenyl ethers of the general formula <FORM:0642159/IV (b)/1> are obtained by reacting a quaternary salt of the general formula <FORM:0642159/IV (b)/2> with a phenol of the general formula <FORM:0642159/IV (b)/3> wherein RN is a tertiary base which may be aliphatic, partly aromatic or one in which the nitrogen is part of a heterocyclic ring, e.g. pyridine, diethylaniline, the picolines, the dimethylpyridines and trimethylpyridines, R1 is one of the groups <FORM:0642159/IV (b)/4> or <FORM:0642159/IV (b)/5> where Z is an alkyl group containing not more than four carbon atoms and Y an acyl group normally used to protect an amino group, R11 is one of the following groups: H, -OH, alkyl, alkoxy, NO2, carbalkoxy, acyloxy and acylamino, and X is the anionic of an aromatic sulphonic acid, hydrochloric acid, hydrobromic acid or hydro-odic acid. The reaction may be carried out in solvents having a dielectric constant of less than 25, e.g. liquid sulphur dioxide, liquid ammonia, benzene or an excess of the tertiary organic base. The reaction may be effected by using the components of the quaternary salt without the isolation of the quaternary salt itself. Examples are given of the preparation of 3 : 5-dinitro-4-(41-hydroxy-or methoxy-phenoxy)-benzylhydantoin; ethyl-3 : 5 - dinitro - 4 - (41 - methoxyphenoxy) - dihydrocinnamate; 3 : 5-dinitro-4-(41-methoxyphenoxy), -4-phenoxy, -4-(41-methylphenoxy), - 4 - (41 - nitrophenoxy), - 4 - (41 - carbomethoxyphenoxy)-toluene; l-3 : 5-dinitro-4-(41-methoxyphenoxy or 41-acetoxyphenoxy) - N - acetylphenylalanine ethyl ester; 3 : 5-dinitro-4-(41-propionyloxyphenoxy)-toluene. Samples have been furnished under Sect. 2(5) of 3 : 5 - dinitro - 4 - (41 - acetamidophenoxy) - toluene; 3 : 5-dinitro-4-(41-acetamidophenoxy)-N-acetyl-dl or l-phenylalamine ethyl ester dl - 5 - 31 : 51 - dinitro - 41 - p - acetamidophenoxybenzyl)-hydantoin; and methyl-3 : 5-dinitro-4-(41-benzamidophenoxy)-benzoate.
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