MODULAR, BIOACTIVE PEPTIDES FOR BINDING NATIVE BONE AND IMPROVING BONE GRAFT OSTEOINDUCTIVITY

摘要

A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of native bone, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.