| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to application of quaternary ammonium compounds, such as benzalkonium chloride, bromide, or iodide or benzethonium chloride, bromide or iodide as medication for prevention precipitation of pradofloxacin of formula(1)or its pharmaceutically acceptable salt or hydrate into sediment from solutions, containing pradofloxacin in amount 0.1-15% (wt/vol), bivalent cations of metals, such as cations of alkali earth metals in amount 0.5-5% (wt/vol), water and pH regulator - the remaining part, as well as medication with antibiotic action, which contains in dissolved form: pradofloxacin in amount 0.1-15% (wt/vol), quaternary ammonium compound, such as benzalkonium chloride, bromide, or iodide or benzethonium chloride, bromide or iodide, bivalent cations of metals, such as cations of alkali earth metals, in particular Mg, in amount 0.5-5% (wt/vol), water and pH regulator.EFFECT: medication preserves stability for 5 years.5 cl, 2 tbl, 8 ex |
