发明名称 |
Synthetic arginine substituted peptides and their use |
摘要 |
The present invention relates to new arginine substituted peptides designed based on the sequence of human lactoferrin and to use thereof, in particular for treatment and/or prevention of infections, inflammations, tumors, pain, wounds and/or scars. |
申请公布号 |
US8815812(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US201113089680 |
申请日期 |
2011.04.19 |
申请人 |
Inger Mattsby-Baltzer |
发明人 |
Mattsby-Baltzer Inger;Dolphin Gunnar |
分类号 |
A61K38/16;A61K38/10;C07K14/435;C07K7/00 |
主分类号 |
A61K38/16 |
代理机构 |
Buchanan Ingersoll & Rooney PC |
代理人 |
Buchanan Ingersoll & Rooney PC |
主权项 |
1. An isolated peptide according to formula (I′) wherein amino acid X1 is Gln or Lys, and amino acid X2 is Asn or Ala; the bond α is an amide bond between the 6-amino group in Lys and the carboxyl group in Ser; n is an integer from 3 to 6; R1 is either no amino acid or the peptide sequence Ala-Thr-Lys-CysM; R2 is either no amino acid or the peptide sequence Pro-Pro-Val-Ser-CysM-Ile-Lys-Arg; CysM is acetamidomethyl-cysteine; wherein a free COOH at a carboxy terminal end optionally has been transformed into CONH2; wherein a free NH2 group at an amino terminal end optionally has been transformed into the amide CH3CONH; and wherein the peptide is selected from the group of peptides consisting of the peptides: |
地址 |
Gothenburg SE |