发明名称 |
Metal-catalyzed copolymerization of imines and carbon monoxide as a route to synthesize polypeptides |
摘要 |
Polypeptides of formula (I):;
wherein R1 and R2 are substituents independently selected from substituted and un-substituted alkyl groups and substituted and un-substituted aryl groups, and n is an integer greater than or equal to 2. Synthesis methods are also provided that do not use amino acids as starting materials, but instead employ imines and carbon monoxide as monomers that undergo transition metal-catalyzed alternating copolymerization to directly provide polypeptides using an acylcobalt catalyst with the following structural formula:
;
wherein R is selected from the group consisting of alkyl, phenyl, and substituted phenyl groups. |
申请公布号 |
US8815913(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US200912480675 |
申请日期 |
2009.06.08 |
申请人 |
Nankai University |
发明人 |
Sun Huailin;Zhang Jian;Liu Qiuhua;Yu Lei;Zhao Jiangyu |
分类号 |
A61K38/00;C07K5/00;C07K7/00;C07K16/00;C07K17/00;C07K2/00;C07K4/00;C07K14/00;C07K1/08;C07K1/02 |
主分类号 |
A61K38/00 |
代理机构 |
Bei & Ocean |
代理人 |
Wang George G.;Bei & Ocean |
主权项 |
1. Polypeptide homopolymers of formula (I) made by copolymerization of imines and carbon monoxide: wherein R1 and R2 are substituents independently selected from the group consisting of substituted or un-substituted alkyl groups, and substituted or un-substituted aryl groups and wherein n is equal or greater than 2. |
地址 |
Tianjin CN |