| 摘要 |
The present invention provides an anti-fungal agent having an excellent anti-fungal action and excellent physicochemical properties such as safety and solubility in water. The present invention discloses a compound represented by the following formula (I) or a salt thereof:
[wherein R 1 represents a hydrogen atom, a halogen atom, an amino group, R 11 -NH-(wherein R 11 represents a C 1-6 alkyl group, a hydroxy C 1-6 alkyl group, a C 1-6 alkoxy C 1-6 alkyl group or a C 1-6 alkoxycarbonyl C 1-6 alkyl group), R 12 -(CO)-NH- (wherein R 12 represents a C 1-6 alkyl group or a C 1-6 alkoxy C 1-6 alkyl group), a C 1-6 alkyl group, a hydroxy C 1-6 alkyl group, a cyano C 1-6 alkyl group, a C 1-6 alkoxy group or a C 1-6 alkoxy C 1-6 alkyl group or a phosphonoamino group; R 2 represents a hydrogen atom, a C 1-6 alkyl group, an amino group or a di C 1-6 alkylamino group or a phosphonoamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C 1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, -CH 2 O-, -OCH 2 -, -NH-, -CH 2 NH-, -NHCH 2 -, -CH 2 S- or -SCH 2 -; R 3 represents a hydrogen atom or a halogen atom or a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-10 aryl group, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R 4 represents a hydrogen atom or halogen atom; provided that either R 1 or R 2 represents a phosphonoamino group.] |
