Peptide derivatives useful in the treatment, care or cleansing of the skin, mucosae, scalp or nails

摘要

The invention relates to peptide derivatives of general formula (I):
R1-AA1-AA2-R3-AA4-R2  (I)
their stereoisomers, mixtures thereof, and their cosmetically or pharmaceutically acceptable salts, a method for obtaining them, cosmetic or pharmaceutical compositions containing them and their use for the treatment, care and/or cleansing of those conditions, disorders and/or pathologies of the skin, mucosae, scalp and/or nails resulting from microorganism proliferation or being at risk of microorganism proliferation.

主权项

1. A peptide of the general formula (I)
R1-AA1-AA2-AA3-AA4-R2  (I)its stereoisomers, or its cosmetically or pharmaceutically acceptable salt, wherein:
AA1 is selected from the group consisting of -Glu- and -Arg-; AA2 is selected from the group consisting of -Met-, -Ahx- and -Phg-; AA3 is selected from the group consisting of -Ala- and -Phg-; AA4 is selected from the group consisting of -Ile- or a single bond; R1 is selected from the group consisting of H, substituted non-cyclic aliphatic group selected from the group consisting of acetyl, tert-butanoyl, hexanoyl, 2-methylhexanoyl, octanoyl, decanoyl, lauroyl, myristoyl, palmitoyl, stearoyl, oleoyl, and linoleoyl, non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, non-substituted heterocyclyl, non-substituted heteroarylalkyl, substituted or non-substituted aryl, non-substituted aralkyl and R5—C(O)—; and R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3; wherein R3 and R4 are independently selected from the group consisting of H, non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, heterocyclyl, non-substituted heteroarylalkyl, substituted or non-substituted aryl, and non-substituted aralkyl; wherein R5 is selected from the group consisting of H, non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, substituted or non-substituted aryl, non-substituted aralkyl, substituted or non-substituted heterocyclyl, and non-substituted heteroarylalkyl.