In situ forming hydrogel and biomedical use thereof

摘要

Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.

主权项

1. A composition of enzyme-triggered in situ-forming injectable hydrogel, represented by the following Chemical Formula 2, comprising:
two or more homogeneous or heterogeneous polymers, represented by the following Chemical Formula 1, bonding to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with one of the phenol or aniline moieties by a linker, wherein the polymers are in situ crosslinked in vivo in the presence of horseradish peroxidase and hydrogen peroxide to form the hydrogel, wherein, R is hydroxyl or amine, and L is selected from the group consisting of polyethyleneglycol (PEG), polyethylene oxide (PEO), polyethylenimine (PEI), polypropylene oxide (PPO), polyvinyl alcohol (PVA), poly(N-isopropylacrylamide) (polyNIPAAM), polyfumarate, polyorganophosphazene, polyacrylic acid (polyAAc), polyacrylsulfonate, poly hydroxyethylmethacrylate(PolyHEMA), and copolymers thereof.