| 主权项 |
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof: wherein:
R1 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R2 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R3 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R4 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12NR13R14, or COR15;R5 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R6 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R7 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R8 is hydrogen, halogen, CN, substituted or unsubstituted C1-6 alkyl, OR12, NR13R14, or COR15;R9 is O, C(O), S, S(O), S(O)2, —C(═NOR16)—;a is 0 or 1;R11 is hydrogen, CN, substituted or unsubstituted C1-6 alkyl, CF3, OR12, NR13R14, substituted or unsubstituted C6-10 aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C2-6 alkyne, substituted or unsubstituted C2-6 alkene or COR15;R12 is hydrogen or substituted or unsubstituted C1-6 alkyl;R13 is hydrogen or substituted or unsubstituted C1-6 alkyl or can from an optionally substituted heterocycle with R14;R14 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted heterocycle or substituted or unsubstituted C6-10 aryl or can from an optionally substituted heterocycle with R13;R15 is hydrogen, hydroxyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C6-10 aryl or substituted or unsubstituted C1-6 alkyl;R16 is hydrogen or substituted or unsubstituted C1-6 alkyl; andR18 is hydrogen or substituted or unsubstituted C1-6 alkyl. |
