| 摘要 |
PROBLEM TO BE SOLVED: To improve throughput of a screening inspection to a congenital metabolism abnormal disease such as an ADA deficiency and the like by shortening a diagnosis time required for one analyte greater than a conventional device and method.SOLUTION: A tandem quadrupole type mass spectrometer is used that employs an ion source 10 by a DART method, and as to a specimen 22 undergoing a pretreatment of adding adenosine to a blood analyte collected from a subject, mass spectrometry is performed that targets metabolites such as inosine and the like supposed to be generated by metabolic action of an ADA. On the basis of a detection signal obtained by a detector 34, a data process section 44 calculates an area value of a peak corresponding to the metabolites, and a diagnosis process section 45 compares the area value with a predetermined threshold value, and thereby determines probability of the ADA deficiency. The mass spectrometry to one specimen is finished in about 10 seconds, and since an exchange of the specimen serving as an analysis object can be automatically carried out at high speed, high throughput can be attained. |
