NOVEL THIENO[3,2-B]PYRIDINYL UREA DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEROF AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING UROTENSIN-II RECEPTOR ACTIVITY RELATED DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a therapeutic use of novel thieno[3,2-b]pyridinyl urea derivatives and U-II receptor activity related diseases thereof. The thieno[3,2-b]pyridinyl urea derivatives, according to the present invention, acts as an antagonist for the U-II receptor, thus can be used for preventing or treating the U-II receptor activity diseases such as congestive heart failure, cardiac ischemia, myocardial infarction, cardiac hypertrophy and fibrosis, coronary heart disease, arteriosclerosis, hypertension, renal failure, diabetes, vascular inflammation, neurodegenerative diseases, stroke, pain, depression, psychosis, and cancer.